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<p>Human exposure to microplastics (MPs) through diet, drinking water and inhalation is a potential public health concern, yet direct evidence of MPs in diseased human tissues remains limited. Using complementary high-resolution techniques, including confocal micro-Raman spectroscopy, Raman imaging–scanning electron microscopy and hyperspectral imaging, we report the in situ detection and characterization of MPs within human intestinal tumour tissues. Among 188 clinical intestinal tumour specimens, MPs were detected in 106 cases (56.4%), with polyethylene terephthalate as the predominant polymer. MP-positive tumours were associated with localized inflammation and histopathological changes, and patients harbouring MP-positive tumours showed a trend towards a higher tumour recurrence rate and considerably elevated gastrointestinal symptom severity over a mean follow-up of 34.1 ± 17.4 months compared with patients with MP-negative tumours. Together, these findings highlight the need for further investigation into exposure pathways, tissue uptake and clearance of MPs, and the potential role of MPs in contributing to the cancer burden.</p>

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Tumour recurrence, gastrointestinal symptoms and inflammation associated with microplastic-positive intestinal tumours

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Honghong Chen,
  • Zhaohui Liu,
  • Wenhui Qiu,
  • Yuping Zhou,
  • Elvis Genbo Xu,
  • Jason T. Magnuson,
  • Jian Zhao,
  • Wenjing Zhao,
  • Shengwei Hou,
  • Huahong Shi,
  • Baoshan Xing,
  • Chunmiao Zheng

摘要

Human exposure to microplastics (MPs) through diet, drinking water and inhalation is a potential public health concern, yet direct evidence of MPs in diseased human tissues remains limited. Using complementary high-resolution techniques, including confocal micro-Raman spectroscopy, Raman imaging–scanning electron microscopy and hyperspectral imaging, we report the in situ detection and characterization of MPs within human intestinal tumour tissues. Among 188 clinical intestinal tumour specimens, MPs were detected in 106 cases (56.4%), with polyethylene terephthalate as the predominant polymer. MP-positive tumours were associated with localized inflammation and histopathological changes, and patients harbouring MP-positive tumours showed a trend towards a higher tumour recurrence rate and considerably elevated gastrointestinal symptom severity over a mean follow-up of 34.1 ± 17.4 months compared with patients with MP-negative tumours. Together, these findings highlight the need for further investigation into exposure pathways, tissue uptake and clearance of MPs, and the potential role of MPs in contributing to the cancer burden.