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<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) increasingly affects young adults, yet this population remains excluded from therapeutic trials and inadequately served by age-biased diagnostic medicine framework for “Generation MASLD” addressing three critical gaps: diagnostic tool failure in younger patients, therapeutic evidence derived exclusively from middle-aged cohorts, and absent transition-of-care frameworks. Urgent action is needed to prevent an emerging public health crisis.</p>

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Generation MASLD: a precision medicine framework for young-onset metabolic dysfunction-associated steatotic liver disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月6日

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  • Victoria Sze Min Ekstrom

摘要

Metabolic dysfunction-associated steatotic liver disease (MASLD) increasingly affects young adults, yet this population remains excluded from therapeutic trials and inadequately served by age-biased diagnostic medicine framework for “Generation MASLD” addressing three critical gaps: diagnostic tool failure in younger patients, therapeutic evidence derived exclusively from middle-aged cohorts, and absent transition-of-care frameworks. Urgent action is needed to prevent an emerging public health crisis.