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<p>The nuclear receptor (NR) superfamily consists of the orphan NR subgroup NR4A, of which Nur77, an immediate early response gene, plays a crucial role in liver physiology and pathophysiology. Nur77 acts as a transcription factor with genomic and non-genomic activities. This review summarises Nur77’s role in liver diseases and its potential as a therapeutic target, as numerous studies have explored the diverse therapeutic implications of targeting Nur77 across different liver diseases.</p>

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Mechanisms of orphan nuclear receptor Nur77 in liver health, disease, and therapeutic potential: narrative review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月1日

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  • Ola Alsharif,
  • Krista Rombouts

摘要

The nuclear receptor (NR) superfamily consists of the orphan NR subgroup NR4A, of which Nur77, an immediate early response gene, plays a crucial role in liver physiology and pathophysiology. Nur77 acts as a transcription factor with genomic and non-genomic activities. This review summarises Nur77’s role in liver diseases and its potential as a therapeutic target, as numerous studies have explored the diverse therapeutic implications of targeting Nur77 across different liver diseases.