<p>The decreasing cost of space travel has intensified interest in space-based manufacturing to support long-term exploration and habitation. High launch costs necessitate utilizing extraterrestrial resources like lunar regolith and recycled space debris for in-space additive manufacturing (ISAM). Metal debris in Earth’s orbit presents a valuable feedstock, while lunar regolith, composed of fine particles, aligns well with powder-based manufacturing techniques. Powder-based additive manufacturing (AM) processes offer design flexibility, reduced material waste, and on-demand production of tools and infrastructure in space. However, powder behavior in microgravity, vacuum conditions, and extreme temperature variations presents significant challenges. Unlike typical AM powders, lunar regolith has a wide size distribution and irregular particle shapes, affecting flowability and printability. Further, certain powder production and characterization methods show greater adaptability to low-pressure environments, while others require modifications to function effectively in microgravity conditions. Reduced gravity amplifies interparticle forces, impacting powder handling and necessitating alternative containment strategies. Various powder characterization techniques are analyzed to determine their viability for space applications, emphasizing the need for modifications to account for non-Earth environments. Furthermore, the study reviews real-time monitoring technologies essential for ensuring print quality in ISAM and highlights recent advancements in computational modeling for predicting powder behavior in space. By refining powder production, characterization, and AM process adaptation, ISAM can minimize reliance on Earth-based supply chains, enabling the construction of tools, habitats, and infrastructure directly in space. Addressing the complexities of powder behavior in non-terrestrial environments will be critical to achieving sustainable, autonomous manufacturing beyond Earth.</p>