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<p>Varying methods have been created to amplify amyloid fibrils using mechanical stresses such as agitation, fluid flow or ultrasonication. In addition, numerous studies have revealed the effects of various kinds of additives on amyloid formation focusing on solvation or macromolecular crowding. This review addresses the mechanism of amyloid formation from the viewpoint of supersaturation- and solubility-limited protein phase transition and development of equipment to induce amyloid formation.</p>

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Mechanism of amyloid fibril formation triggered by breakdown of supersaturation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月3日

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  • Keiichi Yamaguchi,
  • Kichitaro Nakajima,
  • Hirotsugu Ogi,
  • Yuji Goto

摘要

Varying methods have been created to amplify amyloid fibrils using mechanical stresses such as agitation, fluid flow or ultrasonication. In addition, numerous studies have revealed the effects of various kinds of additives on amyloid formation focusing on solvation or macromolecular crowding. This review addresses the mechanism of amyloid formation from the viewpoint of supersaturation- and solubility-limited protein phase transition and development of equipment to induce amyloid formation.