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<p>Cardiac amyloidosis is a progressive infiltrative disease and an important cause of atrial arrhythmias, stroke and heart failure. Abnormal amyloid fibril deposition throughout the heart leads to a host of clinical manifestations and complications. Although atrial abnormalities are typically regarded as a consequence of ventricular diastolic dysfunction or atrial arrhythmias, there is emerging evidence that primary defects of atrial structure and function may be present. An atrial cardiomyopathy may be a sign of early cardiac disease, and an unrecognised independent marker of worse prognosis.</p><p>This review summarizes current evidence specifically for atrial cardiomyopathy in cardiac amyloidosis, with a focus on imaging and clinical outcomes.</p>

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Atrial cardiomyopathy in cardiac amyloidosis: clinical imaging and manifestations

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月4日

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  • Natasha Gorrie,
  • Paul Geenty,
  • Eleanor Rye,
  • Vanathi Sivasubramaniam,
  • Antonia Carroll,
  • Georgia McCaughan,
  • Liza Thomas,
  • Diane Fatkin,
  • Nicole Bart

摘要

Cardiac amyloidosis is a progressive infiltrative disease and an important cause of atrial arrhythmias, stroke and heart failure. Abnormal amyloid fibril deposition throughout the heart leads to a host of clinical manifestations and complications. Although atrial abnormalities are typically regarded as a consequence of ventricular diastolic dysfunction or atrial arrhythmias, there is emerging evidence that primary defects of atrial structure and function may be present. An atrial cardiomyopathy may be a sign of early cardiac disease, and an unrecognised independent marker of worse prognosis.

This review summarizes current evidence specifically for atrial cardiomyopathy in cardiac amyloidosis, with a focus on imaging and clinical outcomes.