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<p>Spreading depolarizations (SDs) contribute to acute brain lesion development. While SDs arise in metabolically compromised tissue, regional determinants of SD-susceptibility remain incompletely understood. Here, we show that SDs preferentially originate in the primary somatosensory cortex (S1) during oxygen-glucose deprivation. Notably, before SD initiation, S1 exhibited a more pronounced decline in ATP compared with other brain regions, suggesting S1-specific metabolic vulnerability as a novel working hypothesis underlying SD initiation.</p>

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ATP-depleting spreading depolarizations preferentially originate in the somatosensory cortex during in situ energy deprivation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Karl Schoknecht,
  • Nicolas G. Höck,
  • Felipe Baeza-Lehnert,
  • Jens P. Dreier,
  • Johannes Hirrlinger,
  • Jens Eilers

摘要

Spreading depolarizations (SDs) contribute to acute brain lesion development. While SDs arise in metabolically compromised tissue, regional determinants of SD-susceptibility remain incompletely understood. Here, we show that SDs preferentially originate in the primary somatosensory cortex (S1) during oxygen-glucose deprivation. Notably, before SD initiation, S1 exhibited a more pronounced decline in ATP compared with other brain regions, suggesting S1-specific metabolic vulnerability as a novel working hypothesis underlying SD initiation.