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<p>Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-throughput platform to assess metabolic health. We summarize key NMR-based models and present a new approach that combines high predictive accuracy with clinical interpretability, identifying disease-specific metabolic distortions and supporting risk stratification and early detection of accelerated aging.</p>

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Metabolomic-based aging clocks

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月3日

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  • A. Ibáñez de Opakua,
  • R. Conde,
  • A. de Diego,
  • M. Bizkarguenaga,
  • N. Embade,
  • S. C. Lu,
  • J. M. Mato,
  • O. Millet

摘要

Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-throughput platform to assess metabolic health. We summarize key NMR-based models and present a new approach that combines high predictive accuracy with clinical interpretability, identifying disease-specific metabolic distortions and supporting risk stratification and early detection of accelerated aging.