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<p>Disrupted light-dark cycles and mistimed feeding are recognized metabolic stressors. In this study, we investigated the independent and combined effects of a 12:12 light:dark cycle, advanced by 6 h every 6 days (Chronic Disruption; CD), and time-restricted feeding on the metabolic health of male C57BL/6J mice. <i>Ad libitum</i> mice under the CD cycle gained significantly more body weight and body fat compared to animals under a control light cycle (LD), despite similar caloric intake and wheel running activity. Using specialized equipment to dissociate light cues from nutrient access, we demonstrate that light-cycle disruption induces metabolic dysfunction specifically through fragmented and misaligned eating patterns. Crucially, restricting food access to a 12-h window synchronized with the shifting dark phase abrogated the weight gain and adiposity observed in the <i>ad libitum</i> group. Conversely, shifting the feeding window under a stable light cycle significantly reduced food intake and weight gain, revealing that feeding regularity is a primary determinant of energy balance independent of light-cycle stability. Overall, while the light-dark cycle is the dominant zeitgeber for activity, the temporal consolidation of food intake is the primary driver of metabolic alignment, offering a potential intervention for managing metabolic risk in shift workers.</p>

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Timing of feeding mitigates metabolic effects of circadian disruption

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月27日

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  • Nathan J. Skinner,
  • Victoria A. Acosta-Rodríguez,
  • Filipa Rijo-Ferreira,
  • Alexander Tups,
  • Joseph S. Takahashi

摘要

Disrupted light-dark cycles and mistimed feeding are recognized metabolic stressors. In this study, we investigated the independent and combined effects of a 12:12 light:dark cycle, advanced by 6 h every 6 days (Chronic Disruption; CD), and time-restricted feeding on the metabolic health of male C57BL/6J mice. Ad libitum mice under the CD cycle gained significantly more body weight and body fat compared to animals under a control light cycle (LD), despite similar caloric intake and wheel running activity. Using specialized equipment to dissociate light cues from nutrient access, we demonstrate that light-cycle disruption induces metabolic dysfunction specifically through fragmented and misaligned eating patterns. Crucially, restricting food access to a 12-h window synchronized with the shifting dark phase abrogated the weight gain and adiposity observed in the ad libitum group. Conversely, shifting the feeding window under a stable light cycle significantly reduced food intake and weight gain, revealing that feeding regularity is a primary determinant of energy balance independent of light-cycle stability. Overall, while the light-dark cycle is the dominant zeitgeber for activity, the temporal consolidation of food intake is the primary driver of metabolic alignment, offering a potential intervention for managing metabolic risk in shift workers.