Scholarlink

<p>Perivascular space (PVS) surrounds cortical perforating vessels as part of the brain clearance system. Sleep affects both brain clearance and functional connectivity (FC), but impacts of PVS on FC remains unclear. We utilized T1-W and resting state-fMRI data, Pittsburgh Sleep Quality Index, and NIH cognitive tests from 512 health aging (HCP-Aging). Basal ganglia (BG)-PVS was positively correlated with FC in the right anterior medial temporal gyrus (aMTG) and right temporal regions, while centrum-semiovale (CSO)-PVS was positively correlated with FC in the left hippocampus and right frontal regions. In early middle-aged, increased CSO-PVS showed higher hippocampal FC and better cognition. Individuals with longer time spent in bed had larger BG-PVS linked to higher FC in the right aMTG. Additionally, older adults with better sleep quality had larger BG-PVS linked to higher FC in the right aMTG. This suggests that PVS morphology may reflect changes in neural connections involved in memory-related regions. This study is based on the same cohort as our previous work; however, it extends the investigation by incorporating functional connectivity analyses to provide novel insights beyond regional activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Perivascular space, brain functional connectivity and sleep: a healthy aging population study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月3日

查看全文
  • Nien-Chu Shih,
  • Joey A. Contreras,
  • Wendy J. Mack,
  • Jeiran Choupan

摘要

Perivascular space (PVS) surrounds cortical perforating vessels as part of the brain clearance system. Sleep affects both brain clearance and functional connectivity (FC), but impacts of PVS on FC remains unclear. We utilized T1-W and resting state-fMRI data, Pittsburgh Sleep Quality Index, and NIH cognitive tests from 512 health aging (HCP-Aging). Basal ganglia (BG)-PVS was positively correlated with FC in the right anterior medial temporal gyrus (aMTG) and right temporal regions, while centrum-semiovale (CSO)-PVS was positively correlated with FC in the left hippocampus and right frontal regions. In early middle-aged, increased CSO-PVS showed higher hippocampal FC and better cognition. Individuals with longer time spent in bed had larger BG-PVS linked to higher FC in the right aMTG. Additionally, older adults with better sleep quality had larger BG-PVS linked to higher FC in the right aMTG. This suggests that PVS morphology may reflect changes in neural connections involved in memory-related regions. This study is based on the same cohort as our previous work; however, it extends the investigation by incorporating functional connectivity analyses to provide novel insights beyond regional activity.