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<p>We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short–half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at <a href="https://famed.ufal.br/ccorgs">https://famed.ufal.br/ccorgs</a>.</p><p></p>

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CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月9日

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  • José Luiz Araújo Santos,
  • Vinícius Tenório Braga Cavalcante Pinto,
  • Thales Eduardo da Silva Santos,
  • Daniel Gomes Coimbra,
  • Tiago Gomes de Andrade

摘要

We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short–half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at https://famed.ufal.br/ccorgs.