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<p>The retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Through melanopsin, light can modulate scWAT metabolism, but its impact on circadian phase is unclear. In vitro exposure of murine scWAT to bright light at different times over 24 h did not elicit phase shifts, unlike the response to corticosterone. This finding suggests that the direct impact of bright light on scWAT metabolism occurs in a circadian-independent manner.</p>

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Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月4日

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  • Anna Edmondson,
  • Charley Beresford,
  • Jan-Frieder Harmsen

摘要

The retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Through melanopsin, light can modulate scWAT metabolism, but its impact on circadian phase is unclear. In vitro exposure of murine scWAT to bright light at different times over 24 h did not elicit phase shifts, unlike the response to corticosterone. This finding suggests that the direct impact of bright light on scWAT metabolism occurs in a circadian-independent manner.