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<p>Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a significant prognostic factor for metastasis-free survival in both luminal BC and ccRCC. Further research is needed to validate PV-1’s prognostic utility, as including it at diagnosis may change the management of these patients and should allow stratification for more aggressive therapies or for closer follow-ups to promptly intervene in case of metastases development.</p>

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PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月21日

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  • Chiara Pozzi,
  • Riccardo Sarti,
  • Antonino Lo Cascio,
  • Stefanos Bonovas,
  • Luca Tiraboschi,
  • Michela Lizier,
  • Alice Bertocchi,
  • Rosalba Torrisi,
  • Bethania Fernandes,
  • Piergiuseppe Colombo,
  • Pietro Diana,
  • Emilia Maria Cristina Mazza,
  • Marina Valeri,
  • Salvatore Lorenzo Renne,
  • Ferdinando Carlo Maria Cananzi,
  • Laura Samà,
  • Alexia Bertuzzi,
  • Corrado Tinterri,
  • Massimo Lazzeri,
  • Maria Rescigno

摘要

Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a significant prognostic factor for metastasis-free survival in both luminal BC and ccRCC. Further research is needed to validate PV-1’s prognostic utility, as including it at diagnosis may change the management of these patients and should allow stratification for more aggressive therapies or for closer follow-ups to promptly intervene in case of metastases development.