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<p>Cytokinesis is a key process in the development of multicellular organisms, through both formative and proliferative divisions. In land plants, successful cytokinesis requires precise targeting of Golgi-derived vesicles to the future cell division plane by the phragmoplast, a cytoskeletal structure that undergoes continuous remodeling. Endomembrane trafficking and phragmoplast remodeling are tightly coupled, indicating the existence of active crosstalk. However, although many molecular regulators of membrane trafficking and cytoskeletal organization are known, it remains poorly understood how these processes are coordinated. Here, we describe a regulatory module consisting of the membrane-associated GTPase RAB-A2a, cytoskeleton-associated Class II Kinesin-12 proteins, and the Fused kinase ortholog TIO. We provide evidence that the interaction between these molecules at the midzone, and differential functions of Class II Kinesin-12 members at the leading and lagging cell plate domains, are essential for cytokinesis initiation and progression in <i>Arabidopsis</i> by simultaneously targeting vesicles to the midzone and coupling phragmoplast remodeling to vesicle delivery.</p>

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A Rab/Kinesin-12/kinase module couples vesicle delivery and phragmoplast dynamics during plant cell cytokinesis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月15日

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  • Liam Elliott,
  • Moé Yamada,
  • Monika Kalde,
  • Michal Hála,
  • Andrei Smertenko,
  • Frédérique Rozier,
  • James Evry,
  • Niloufer Irani,
  • Yvon Jaillais,
  • Patrick J Hussey,
  • Viktor Žárský,
  • Ian Moore,
  • Roman Pleskot,
  • Charlotte Kirchhelle

摘要

Cytokinesis is a key process in the development of multicellular organisms, through both formative and proliferative divisions. In land plants, successful cytokinesis requires precise targeting of Golgi-derived vesicles to the future cell division plane by the phragmoplast, a cytoskeletal structure that undergoes continuous remodeling. Endomembrane trafficking and phragmoplast remodeling are tightly coupled, indicating the existence of active crosstalk. However, although many molecular regulators of membrane trafficking and cytoskeletal organization are known, it remains poorly understood how these processes are coordinated. Here, we describe a regulatory module consisting of the membrane-associated GTPase RAB-A2a, cytoskeleton-associated Class II Kinesin-12 proteins, and the Fused kinase ortholog TIO. We provide evidence that the interaction between these molecules at the midzone, and differential functions of Class II Kinesin-12 members at the leading and lagging cell plate domains, are essential for cytokinesis initiation and progression in Arabidopsis by simultaneously targeting vesicles to the midzone and coupling phragmoplast remodeling to vesicle delivery.