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<p>Imaging is essential for probing cancer biology and tumor surveillance in humans. Combining isotopically labeled substrates with advanced imaging approaches yields a new platform, metabolic imaging. Although cancer metabolism research began ~100 years ago, breakthroughs in magnetic resonance imaging (MRI) like hyperpolarization, deuterium metabolic imaging, and novel probes have revolutionized our ability to appreciate deregulated glycolysis in cancer. Here, we discuss the state and future of glycolytic imaging with MRI.</p>

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The state of imaging glycolytic metabolism in cancer with magnetic resonance

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月10日

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  • Mario C. Chang,
  • Matthew E. Merritt,
  • Kayvan R. Keshari

摘要

Imaging is essential for probing cancer biology and tumor surveillance in humans. Combining isotopically labeled substrates with advanced imaging approaches yields a new platform, metabolic imaging. Although cancer metabolism research began ~100 years ago, breakthroughs in magnetic resonance imaging (MRI) like hyperpolarization, deuterium metabolic imaging, and novel probes have revolutionized our ability to appreciate deregulated glycolysis in cancer. Here, we discuss the state and future of glycolytic imaging with MRI.