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<p>Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study characterized longitudinal CD8<sup>+</sup> T cell responses in an orthotopic mouse model of breast cancer treated with radiation and anti-CTLA4 by immunohistochemistry and anti-CD8 immunoPET, confirming an early but heterogeneous response induced by combination treatment that is detectable by imaging.</p>

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89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Elizabeth A. Germino,
  • Kirstin A. Zettlitz,
  • Tyler Watkins,
  • Bao Ying Chen,
  • Deirdre La Placa,
  • Felix B. Salazar,
  • Jennifer Chean,
  • Shichang Li,
  • Heather M. McGee,
  • Terence M. Williams,
  • Anna M. Wu

摘要

Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study characterized longitudinal CD8+ T cell responses in an orthotopic mouse model of breast cancer treated with radiation and anti-CTLA4 by immunohistochemistry and anti-CD8 immunoPET, confirming an early but heterogeneous response induced by combination treatment that is detectable by imaging.