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<p>The combination therapy of FDA approved oxidative phosphorylation inhibitors (metformin and atovaquone) and platelet derived growth factor inhibitors (sunitinib and sorafenib) could target ovarian cancer stem-like cells (CSCs) and carcinoma associated mesenchymal stem cell enrichment of CSCs while reducing off-target effects. Results of a 48-hour drug exposure ovarian cancer-MSC tumoroid model showed additive effects with atovaquone combined with sunitinib or sorafenib being most effective.</p>

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Combination of oxidative phosphorylation and platelet-derived growth factor inhibitors for the treatment of ovarian cancers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月7日

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  • Kathleen M. Burkhard,
  • Taylor Repetto,
  • Geeta Mehta

摘要

The combination therapy of FDA approved oxidative phosphorylation inhibitors (metformin and atovaquone) and platelet derived growth factor inhibitors (sunitinib and sorafenib) could target ovarian cancer stem-like cells (CSCs) and carcinoma associated mesenchymal stem cell enrichment of CSCs while reducing off-target effects. Results of a 48-hour drug exposure ovarian cancer-MSC tumoroid model showed additive effects with atovaquone combined with sunitinib or sorafenib being most effective.