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<p>Endometriosis postoperative recurrence remains a major clinical challenge and a poorly understood biological process, directly impacting long-term care. This narrative review integrates current knowledge on recurrence definitions, patterns, risk factors, and prevention strategies; potential predictive models and candidate biomarkers; and surgical and biological contributors to recurrence. We propose that recurrent endometriosis represents a valuable model that may help uncover disease mechanisms and guide future research toward personalized, mechanism-based management strategies.</p>

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Rethinking endometriosis recurrence: from clinical challenge to biological opportunity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月14日

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  • Carina Masferrer-Ferragutcasas,
  • Raquel Delgado-Gil,
  • Eva Colas

摘要

Endometriosis postoperative recurrence remains a major clinical challenge and a poorly understood biological process, directly impacting long-term care. This narrative review integrates current knowledge on recurrence definitions, patterns, risk factors, and prevention strategies; potential predictive models and candidate biomarkers; and surgical and biological contributors to recurrence. We propose that recurrent endometriosis represents a valuable model that may help uncover disease mechanisms and guide future research toward personalized, mechanism-based management strategies.