Pathways from early-life urbanicity to adult neurobehavioral traits via menarche timing
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期刊论文
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发表日期：
2025年12月15日
- Lining Guo,
- Feng Liu,
- Wenshuang Zhu,
- Jingliang Cheng,
- Longjiang Zhang,
- Bing Zhang,
- Wenzhen Zhu,
- Shijun Qiu,
- Zuojun Geng,
- Guangbin Cui,
- Quan Zhang,
- Weihua Liao,
- Bo Gao,
- Xiaojun Xu,
- Tong Han,
- Zhenwei Yao,
- Wen Qin,
- Meng Liang,
- Kaizhong Xue,
- Qiang Xu,
- Jilian Fu,
- Jiayuan Xu,
- Nana Liu,
- Peng Zhang,
- Wei Li,
- Dapeng Shi,
- Jia-Hong Gao,
- Su Lui,
- Zhihan Yan,
- Feng Chen,
- Yunjun Yang,
- Jing Zhang,
- Dawei Wang,
- Wen Shen,
- Yanwei Miao,
- Junfang Xian,
- Le Yu,
- Kai Xu,
- Meiyun Wang,
- Zhaoxiang Ye,
- Xiaochu Zhang,
- Xi-Nian Zuo,
- Yongqiang Yu,
- Hui Zhang,
- Chunshui Yu,
- Quan Zhang,
- Junping Wang,
- Xue Zhang,
- Xinjun Suo,
- Congcong Yuan,
- Yuan Ji,
- Hui Xue,
- Tianying Gao,
- Junpeng Liu,
- Yanjun Li,
- Xi Guo,
- Lixue Xu,
- Jiajia Zhu,
- Huaigui Liu,
- Fangshi Zhao,
- Jie Sun,
- Yongjie Xu,
- Huanhuan Cai,
- Jie Tang,
- Yaodan Zhang,
- Yongqin Xiong,
- Xianting Sun,
- Nannan Pan,
- Xue Zhang Jr.,
- Jiayang Yang,
- Ya Wen,
- Dan Zhu,
- Bingjie Wu,
- Qingqing Diao,
- Yujuan Cao,
- Bingbing Yang,
- Yingying Xie,
- Jiahui Lin,
- Zhimin Li,
- Yan Zhang,
- Zirui Wang,
- Junlin Shen,
- Xuejun Zhang,
- Hao Ding,
- Qian Su,
- Mulin Jun Li,
- Shijie Zhang,
- Jianhua Wang,
- Lun Ma,
- Yan Bai,
- Min Guan,
- Wei Wei,
- Caihong Wang,
- Peifang Miao,
- Fuhong Duan,
- Yafei Guo,
- Weijian Wang,
- Lijuan Zheng,
- Li Lin,
- Yunfei Wang,
- Han Zhang,
- Xinyuan Zhang,
- Zhao Qing,
- Sichu Wu,
- Junxia Wang,
- Yi Sun,
- Yang He,
- Zhe Zhang,
- Yin-Shan Wang,
- Quan Zhou,
- Tian Tian,
- Yi Liang,
- Yujie Liu,
- Hui Zeng,
- Jingxian Chen,
- Haitao Ge,
- Peng Xu,
- Cailuan Lu,
- Chen Wu,
- Xiaoying Yang,
- Yuzhao Wang,
- Yankai Wu,
- Xuran Feng,
- Ling Li,
- Duo Gao,
- Rujing Zha,
- Ying Li,
- Lizhuang Yang,
- Ying Chen,
- Ling Zuo,
- Jianqiao Ge,
- Guoyuan Yang,
- Wen Wang,
- Linfeng Yan,
- Yang Yang,
- Jin Zhang,
- Qian Wang,
- Xiaoxia Qu,
- Ying Wang,
- Fei Yuan,
- Li Hu,
- Jizhen Li,
- Weiwei Wang,
- Yujing Zhou,
- Miaomiao Long,
- Lihua Liu,
- Xiaohu Li,
- Xiaoshu Li,
- Jiance Li,
- Nengzhi Xia,
- Shuai Yang,
- Youming Zhang,
- Guangyao Liu,
- Laiyang Ma,
- Xiaochun Wang,
- Ying Lei,
- Gang Zhang,
- Kang Yuan,
- Jingjing Xu,
- Xiaojun Guan,
- Yuankai Lin,
- Huijuan Chen,
- Yuchuan Fu,
- Yi Lu,
- Jun Guo,
- Hao Lu,
- Yue Wu
摘要
The mechanism by which the increasing environmental challenge of urbanicity impacts the brain, personality and mental disorders remains unclear. Here, grounded in life history theory, we tested the hypothesis that age at menarche (AAM) mediates the effects of early-life urbanicity on adult regional brain volumes and personality traits associated with mental disorders. In a sample of 2,950 young Chinese women, we discovered that higher levels of early-life urbanicity were associated with earlier AAM, which in turn correlated with reduced medial prefrontal volume and lower levels of agreeableness and reward dependence in adulthood. Urbanicity-related factors, particularly family socioeconomic status, also influenced these neurobehavioral traits through AAM. The urbanicity- and AAM-related brain and personality traits were changed in patients with major depressive disorder and schizophrenia. These findings suggest that life history theory may serve as a mechanism through which early-life urbanicity influences the adult brain and personality traits associated with mental disorders in women.