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<p>Genomics research is essential for understanding the transmission and evolution of bacterial antimicrobial resistance. The development of nanopore long-read sequencing has revolutionized our understanding of the prevalence, spread, and dynamic evolution of bacterial ARGs. This review discusses the applications and advantages of nanopore sequencing technology in the complete bacterial genome construction, rapid ARG detection, and dynamic evolution analysis of multidrug resistance genetic structure. We emphasize the unique advantages of long-read nanopore sequencing in analyzing the genetic contexts of ARGs in both cultured bacteria and microbiota, as well as the rapid turnaround time for clinical bacterial resistance detection. Technical advancements and the future potential for expanding the applications of nanopore sequencing in the field of antimicrobial resistance are discussed.</p>

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The applications and advantages of nanopore sequencing in bacterial antimicrobial resistance surveillance and research

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月27日

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  • Kai Peng,
  • Changan Li,
  • Qiaojun Wang,
  • Xueqiang Xin,
  • Zhiqiang Wang,
  • Ruichao Li

摘要

Genomics research is essential for understanding the transmission and evolution of bacterial antimicrobial resistance. The development of nanopore long-read sequencing has revolutionized our understanding of the prevalence, spread, and dynamic evolution of bacterial ARGs. This review discusses the applications and advantages of nanopore sequencing technology in the complete bacterial genome construction, rapid ARG detection, and dynamic evolution analysis of multidrug resistance genetic structure. We emphasize the unique advantages of long-read nanopore sequencing in analyzing the genetic contexts of ARGs in both cultured bacteria and microbiota, as well as the rapid turnaround time for clinical bacterial resistance detection. Technical advancements and the future potential for expanding the applications of nanopore sequencing in the field of antimicrobial resistance are discussed.