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<p>Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynamic, regulated trait responsive to environmental cues and selection pressures. This review examines the regulatory mechanisms controlling PCN and its impact on the trade-offs between bacterial fitness, virulence cost, and antibiotic resistance.</p><p></p>

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Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月18日

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  • Helen Wang,
  • Enrique Joffré

摘要

Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynamic, regulated trait responsive to environmental cues and selection pressures. This review examines the regulatory mechanisms controlling PCN and its impact on the trade-offs between bacterial fitness, virulence cost, and antibiotic resistance.