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<p>Antimicrobial-resistant <i>Enterobacteriaceae</i> are increasingly a clinical challenge. In particular, extraintestinal pathogenic <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections while maintaining current clinical therapies. The review aims to emphasize the need for vaccines targeting extraintestinal pathogenic <i>E. coli</i> and <i>K. pneumoniae</i> by providing an overview of disease burden, antimicrobial resistance, therapeutics, and vaccine development.</p>

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Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月28日

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  • Adriana Cabrera,
  • Emily Mason,
  • Liam P. Mullins,
  • Manish Sadarangani

摘要

Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections while maintaining current clinical therapies. The review aims to emphasize the need for vaccines targeting extraintestinal pathogenic E. coli and K. pneumoniae by providing an overview of disease burden, antimicrobial resistance, therapeutics, and vaccine development.