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<p>Nano-bio interfaces are crucial points of interaction between synthetic materials and biological systems at the nanoscale, facilitating the exchange of information and access to biological processes. In this Review, we discuss the design and fabrication of nano-bio interfaces, focusing on the materials, topography and surface chemistry that determine their functionality and the information that can be measured. We highlight the design of nano-bio interfaces for bioelectrical signal detection in heart and brain tissue as well as for biochemical signal transduction across the cell membrane to investigate how cells sense and respond to extracellular environments and physical forces at the nanoscale. Finally, we outline key future milestones in the fabrication and application of nano-bio interfaces, emphasizing the need to overcome technical barriers to provide accessible devices.</p>

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Nano-bio interfaces for electrical and biochemical signal transduction

  • 期刊论文

  • 发表日期：

    2025年11月5日

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  • Xiao Yang,
  • Ching-Ting Tsai,
  • Yang Yang,
  • Wei Zhang,
  • He You,
  • Csaba Forró,
  • Sergiu P. Pașca,
  • Bianxiao Cui

摘要

Nano-bio interfaces are crucial points of interaction between synthetic materials and biological systems at the nanoscale, facilitating the exchange of information and access to biological processes. In this Review, we discuss the design and fabrication of nano-bio interfaces, focusing on the materials, topography and surface chemistry that determine their functionality and the information that can be measured. We highlight the design of nano-bio interfaces for bioelectrical signal detection in heart and brain tissue as well as for biochemical signal transduction across the cell membrane to investigate how cells sense and respond to extracellular environments and physical forces at the nanoscale. Finally, we outline key future milestones in the fabrication and application of nano-bio interfaces, emphasizing the need to overcome technical barriers to provide accessible devices.