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<p>Post-traumatic stress (PTS) is highly comorbid with depression but understudied among perinatal populations. Here, using Scaling Up Maternal Mental healthcare by Increasing access to Treatment Trial (<a href="http://clinicaltrials.gov/ct2/show/NCT04153864?term=NCT04153864">NCT04153864</a>) data on trauma, we examined (1) the prevalence and correlates of baseline PTS symptoms among perinatal patients with comorbid depressive symptoms, (2) the potential impact of an eight-session behavioral activation (BA) on PTS symptoms at 3 months post-randomization and (3) the potential moderators of PTS symptoms. We included 1,102 participants who received ≥1 BA session and completed the six-item Post-Traumatic Stress Disorder Checklist Checklist (PCL-6). At baseline, 69.78% of the patients met the clinical thresholds for PTS symptom criteria (PCL-6 ≥14) and relevant correlates included socioeconomic (lower income and education, and higher unemployment) and clinical (greater psychotropic medication use and symptoms of depressive and anxiety) variables. The PTS scores decreased significantly from baseline to 3 months (PCL-6 decreased from 18.17 to 14.68, <i>P</i> &lt; 0.0001) and were moderated by baseline PTS severity, and not by baseline depressive symptoms, race/ethnicity or perinatal period. Thus, BA may be an effective treatment option for comorbid PTS symptoms, regardless of sociodemographic characteristics.</p>

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Treating comorbid post-traumatic stress and depression in perinatal populations: findings from a pragmatic randomized controlled trial

  • 期刊论文

  • 发表日期：

    2025年10月8日

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  • Daisy R. Singla,
  • Tara S. Berenbaum,
  • Richard K. Silver,
  • Simone N. Vigod,
  • Siying Li,
  • Aditya Anand,
  • Sandeep Shelly,
  • Alex Kiss,
  • Andrea S. Lawson,
  • Lucy C. Barker,
  • Steven D. Hollon,
  • Bradley N. Gaynes,
  • Paula Ravitz,
  • Crystal E. Schiller,
  • Samantha Meltzer-Brody,
  • Vikram Patel

摘要

Post-traumatic stress (PTS) is highly comorbid with depression but understudied among perinatal populations. Here, using Scaling Up Maternal Mental healthcare by Increasing access to Treatment Trial (NCT04153864) data on trauma, we examined (1) the prevalence and correlates of baseline PTS symptoms among perinatal patients with comorbid depressive symptoms, (2) the potential impact of an eight-session behavioral activation (BA) on PTS symptoms at 3 months post-randomization and (3) the potential moderators of PTS symptoms. We included 1,102 participants who received ≥1 BA session and completed the six-item Post-Traumatic Stress Disorder Checklist Checklist (PCL-6). At baseline, 69.78% of the patients met the clinical thresholds for PTS symptom criteria (PCL-6 ≥14) and relevant correlates included socioeconomic (lower income and education, and higher unemployment) and clinical (greater psychotropic medication use and symptoms of depressive and anxiety) variables. The PTS scores decreased significantly from baseline to 3 months (PCL-6 decreased from 18.17 to 14.68, P < 0.0001) and were moderated by baseline PTS severity, and not by baseline depressive symptoms, race/ethnicity or perinatal period. Thus, BA may be an effective treatment option for comorbid PTS symptoms, regardless of sociodemographic characteristics.