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<p>Methamphetamine use disorder (MUD) is a substantial public health crisis characterized by neurobiological abnormalities. Although neurofunctional variations across abstinence stages are documented, brain connectivity patterns associated with abstinence duration remain poorly characterized. In this cross-sectional study, we characterize brain connectivity patterns associated with abstinence duration in MUD. We hypothesize that whole-brain functional connectivity patterns would covary with abstinence duration in MUD. Applying connectome-based predictive modeling with leave-one-out cross-validation to resting-state functional connectivity data from participants with MUD stratified by abstinence duration (&lt;1 month, 1–3 months, 3–6 months, 6–24 months; total <i>N</i> = 85), we identified patterns significantly associated with abstinence duration (<i>r</i> = 0.51, <i>P</i> &lt; 0.001), validated in an independent cohort (<i>N</i> = 48, <i>r</i> = 0.41, <i>P</i> &lt; 0.004). These patterns comprised positive components showing strengthened within-network connectivity in motor/sensory, subcortical and medial frontal networks, and enhanced between-network connectivity involving motor/sensory, cerebellum/brainstem and subcortical networks, and negative components demonstrating reduced connectivity between motor/sensory and default mode networks, as well as among motor/sensory, medial frontal and visual association networks. Exploratory analyses revealed systematic variation in strength, with healthy comparison individuals exhibiting intermediate connectivity relative to individuals who were short-term (&lt;1 month) versus prolonged (6–24 months) MUD-abstinent. Our findings reveal cross-sectional associations between abstinence duration and brain connectivity in MUD.</p>

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Brain connectivity patterns associated with duration of abstinence in methamphetamine use disorder

  • 期刊论文

  • 发表日期：

    2025年9月18日

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  • Gangliang Zhong,
  • Tianzhen Chen,
  • Hang Su,
  • Xiaotong Li,
  • Na Zhong,
  • Haifeng Jiang,
  • Yuzheng Hu,
  • Marc N. Potenza,
  • Jiang Du,
  • Min Zhao

摘要

Methamphetamine use disorder (MUD) is a substantial public health crisis characterized by neurobiological abnormalities. Although neurofunctional variations across abstinence stages are documented, brain connectivity patterns associated with abstinence duration remain poorly characterized. In this cross-sectional study, we characterize brain connectivity patterns associated with abstinence duration in MUD. We hypothesize that whole-brain functional connectivity patterns would covary with abstinence duration in MUD. Applying connectome-based predictive modeling with leave-one-out cross-validation to resting-state functional connectivity data from participants with MUD stratified by abstinence duration (<1 month, 1–3 months, 3–6 months, 6–24 months; total N = 85), we identified patterns significantly associated with abstinence duration (r = 0.51, P < 0.001), validated in an independent cohort (N = 48, r = 0.41, P < 0.004). These patterns comprised positive components showing strengthened within-network connectivity in motor/sensory, subcortical and medial frontal networks, and enhanced between-network connectivity involving motor/sensory, cerebellum/brainstem and subcortical networks, and negative components demonstrating reduced connectivity between motor/sensory and default mode networks, as well as among motor/sensory, medial frontal and visual association networks. Exploratory analyses revealed systematic variation in strength, with healthy comparison individuals exhibiting intermediate connectivity relative to individuals who were short-term (<1 month) versus prolonged (6–24 months) MUD-abstinent. Our findings reveal cross-sectional associations between abstinence duration and brain connectivity in MUD.