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<p>Childhood maltreatment has long-term effects on brain structure, inflammation and psychiatric symptoms, yet its impact on white matter (WM) integrity in bipolar disorder type II depression (BDII-D) remains understudied. Here, we investigate WM alterations in BDII-D and their associations with childhood maltreatment, inflammation and psychiatric symptoms. Using TractSeg, we analyzed WM integrity in 146 patients with BDII-D and 151 healthy controls, identifying significantly lower fractional anisotropy (FA) in the corpus callosum, left inferior longitudinal fasciculus and right striato-fronto-orbital tract, alongside higher FA in sensory-motor regions. WM alterations were correlated with inflammatory markers and psychiatric symptoms. Non-negative matrix factorization and clustering analysis revealed two BDII-D subgroups, with one subgroup showing lower corpus callosum FA, higher inflammatory markers, greater childhood emotional maltreatment and psychiatric symptoms. These findings suggest deficits in WM integrity in thalamo-subcortical-cortical and somatosensory areas in BDII-D. Childhood emotional maltreatment may contribute to long-term effects on inflammation and psychiatric symptoms in adulthood BDII-D.</p>

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Associations among bipolar II depression white matter subgroups, inflammation, symptoms and childhood maltreatment

  • 期刊论文

  • 发表日期：

    2025年5月26日

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  • Yuan Cao,
  • Paulo Lizano,
  • Meng Li,
  • Lejla Colic,
  • Tara Chand,
  • Nooshin Javaheripour,
  • Huan Sun,
  • Gaoju Deng,
  • Xiaoqin Zhou,
  • Xipeng Long,
  • Qiyong Gong,
  • Changjian Qiu,
  • Martin Walter,
  • Zhiyun Jia

摘要

Childhood maltreatment has long-term effects on brain structure, inflammation and psychiatric symptoms, yet its impact on white matter (WM) integrity in bipolar disorder type II depression (BDII-D) remains understudied. Here, we investigate WM alterations in BDII-D and their associations with childhood maltreatment, inflammation and psychiatric symptoms. Using TractSeg, we analyzed WM integrity in 146 patients with BDII-D and 151 healthy controls, identifying significantly lower fractional anisotropy (FA) in the corpus callosum, left inferior longitudinal fasciculus and right striato-fronto-orbital tract, alongside higher FA in sensory-motor regions. WM alterations were correlated with inflammatory markers and psychiatric symptoms. Non-negative matrix factorization and clustering analysis revealed two BDII-D subgroups, with one subgroup showing lower corpus callosum FA, higher inflammatory markers, greater childhood emotional maltreatment and psychiatric symptoms. These findings suggest deficits in WM integrity in thalamo-subcortical-cortical and somatosensory areas in BDII-D. Childhood emotional maltreatment may contribute to long-term effects on inflammation and psychiatric symptoms in adulthood BDII-D.