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<p>Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); <i>N</i> = 750) and older adult (71.1 ± 5.9 years; <i>N</i> = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.</p>

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Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月2日

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  • David Bartrés-Faz,
  • Harriet Demnitz-King,
  • María Cabello-Toscano,
  • Lídia Vaqué-Alcázar,
  • Rob Saunders,
  • Edelweiss Touron,
  • Gabriele Cattaneo,
  • Julie Gonneaud,
  • Olga Klimecki,
  • Núria Bargalló,
  • Javier Sánchez-Solana,
  • José M. Tormos,
  • Gäel Chételat,
  • Álvaro Pascual-Leone,
  • Natalie L. Marchant,
  • Claire André,
  • Romain Bachelet,
  • Sebastian Baez Lugo,
  • Anne Chocat,
  • Fabienne Collette,
  • Nina Coll-Padros,
  • Sophie Dautricourt,
  • Vincent De La Sayette,
  • Marion Delarue,
  • Eglantine Ferrand Devouge,
  • Eric Frison,
  • Karine Goldet,
  • Frank Jessen,
  • Pierre Krolak-Salmon,
  • Elizabeth Kuhn,
  • Brigitte Landeau,
  • Valérie Lefranc,
  • Antoine Lutz,
  • Florence Mezenge,
  • Dix Meiberth,
  • Laurence Michel,
  • José Luis Molinuevo,
  • Valentin Ourry,
  • Géraldine Poisnel,
  • Anne Quillard,
  • Géraldine Rauchs,
  • Eric Salmon,
  • Ann-Katrin Schild,
  • Corinne Schimmer,
  • Delphine Smagghe,
  • Rhonda Smith,
  • Marco Schlosser,
  • Patrik Vuilleumier,
  • Cédrick Wallet,
  • Zuzana Walker,
  • Tim Whitfield,
  • Miranka Wirth

摘要

Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); N = 750) and older adult (71.1 ± 5.9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.