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<p>This study assessed the preliminary effectiveness of a game-based digital therapeutics (DTx) intervention for depression and anxiety using a randomized controlled trial (RCT) design to examine the role of reinforcement learning (RL) personalization. This RCT included 223 individuals with depressive symptoms, aged 18–50, divided into three groups: an RL Algorithm group (personalized treatment), an active control group (fixed treatment), and a no-intervention control group. The intervention combined cognitive bias modification and cognitive behavioral therapy, with outcomes measured by the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7. Results showed significantly higher treatment response and recovery rates in the RL Algorithm group compared to the no-intervention group. The game-based DTx intervention, enhanced by RL personalization, effectively reduced depression and anxiety symptoms, supporting its potential for mental health treatment. The study was registered at clinicaltrials.gov (NCT06301555).</p>

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Personalized game-based digital intervention for relieving depression and anxiety symptoms: a pilot RCT

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Xiaojun Shao,
  • Lu Liu,
  • Xiaotong Zhu,
  • Chunsheng Tian,
  • Dai Li,
  • Liqun Zhang,
  • Xiang Liu,
  • Yanru Liu,
  • Gang Zhu,
  • Lingjiang Li

摘要

This study assessed the preliminary effectiveness of a game-based digital therapeutics (DTx) intervention for depression and anxiety using a randomized controlled trial (RCT) design to examine the role of reinforcement learning (RL) personalization. This RCT included 223 individuals with depressive symptoms, aged 18–50, divided into three groups: an RL Algorithm group (personalized treatment), an active control group (fixed treatment), and a no-intervention control group. The intervention combined cognitive bias modification and cognitive behavioral therapy, with outcomes measured by the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7. Results showed significantly higher treatment response and recovery rates in the RL Algorithm group compared to the no-intervention group. The game-based DTx intervention, enhanced by RL personalization, effectively reduced depression and anxiety symptoms, supporting its potential for mental health treatment. The study was registered at clinicaltrials.gov (NCT06301555).