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<p>Psychiatric research has shifted from a <i>neuroncentric</i> view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)— actively involved in the modulation of neuronal functions – are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.</p>

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Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月15日

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  • Giulia Poggi,
  • Giulia Treccani,
  • Martina von der Bey,
  • Arnaud Tanti,
  • Michael J. Schmeisser,
  • Marianne Müller

摘要

Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)— actively involved in the modulation of neuronal functions – are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.