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Background <p>Black and African American women face a dual burden of elevated risk of preterm birth (PTB, &lt;37 weeks of gestation) and exposure to polybrominated diphenyl ethers (PBDE), endocrine-disrupting pollutants. Although prenatal PBDE levels have been linked to PTB, underlying mechanisms remain unclear.</p> Methods <p>We examined serum PBDE levels and metabolomic profiles in 177 pregnant participants (18–40 years old) from the Atlanta African American Maternal-Child Cohort (2014–2019). BDE-47, −100, and −99 were quantified in maternal serum collected at 8–14 weeks’ gestation using chromatography-tandem mass spectrometry. Untargeted metabolomics profiling was conducted on maternal serum samples collected during the same period via high-resolution mass spectrometry. Generalized linear models were used to conduct metabolome-wide association studies to identify features linking PBDE levels to PTB.</p> Results <p>Here we find that 46 (26%) of 177 participants experienced PTB. Twenty-six metabolites, which were confirmed with Level One evidence according to the Metabolomics Standard Initiatives, are associated with maternal PBDE levels and/or PTB. These metabolites suggest disruptions in thiamine-dependent pathways, cysteine and methionine metabolism, the carnitine shuttle, and glycerophospholipid metabolism.</p> Conclusions <p>These findings suggest that PBDE-associated perturbations in oxidative stress, inflammation, and energy metabolism may be mechanisms through which environmental exposures contribute to PTB risk in populations disproportionately exposed.</p>

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High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月20日

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  • Siddhi S. Desai,
  • Anne L. Dunlop,
  • Dana Boyd Barr,
  • Paula-Dene C. Nesbeth,
  • Susan S. Hoffman,
  • Youran Tan,
  • Mengyuan Ren,
  • ViLinh T. Tran,
  • Grace Lee,
  • Parinya Panuwet,
  • Stephanie M. Eick,
  • P. Barry Ryan,
  • Dean P. Jones,
  • Donghai Liang

摘要

Background

Black and African American women face a dual burden of elevated risk of preterm birth (PTB, <37 weeks of gestation) and exposure to polybrominated diphenyl ethers (PBDE), endocrine-disrupting pollutants. Although prenatal PBDE levels have been linked to PTB, underlying mechanisms remain unclear.

Methods

We examined serum PBDE levels and metabolomic profiles in 177 pregnant participants (18–40 years old) from the Atlanta African American Maternal-Child Cohort (2014–2019). BDE-47, −100, and −99 were quantified in maternal serum collected at 8–14 weeks’ gestation using chromatography-tandem mass spectrometry. Untargeted metabolomics profiling was conducted on maternal serum samples collected during the same period via high-resolution mass spectrometry. Generalized linear models were used to conduct metabolome-wide association studies to identify features linking PBDE levels to PTB.

Results

Here we find that 46 (26%) of 177 participants experienced PTB. Twenty-six metabolites, which were confirmed with Level One evidence according to the Metabolomics Standard Initiatives, are associated with maternal PBDE levels and/or PTB. These metabolites suggest disruptions in thiamine-dependent pathways, cysteine and methionine metabolism, the carnitine shuttle, and glycerophospholipid metabolism.

Conclusions

These findings suggest that PBDE-associated perturbations in oxidative stress, inflammation, and energy metabolism may be mechanisms through which environmental exposures contribute to PTB risk in populations disproportionately exposed.