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Background <p>Vaccine-preventable diseases and common viral infections pose substantial public health challenges worldwide. Applying multiplex serological assays to samples collected from cross-sectional studies allows assessment of population-level immunity to a broad range of pathogens.</p> Methods <p>We develop a high-throughput multiplex serological assay using bead-based Luminex technology to measure IgG antibody responses to a broad panel of pathogens. Vaccine preventable diseases include pertussis, diphtheria, tetanus, measles, mumps, and rubella. Common viral infections include adenovirus, cytomegalovirus, Epstein-Barr virus, chickenpox, respiratory syncytial virus, echovirus, Coxsackie B virus, rhinovirus, norovirus, rotavirus, influenza A, hepatitis A, hepatitis E, and the seasonal coronaviruses 229E, OC43, NL63, and HKU1. Measured antibody responses are analysed with statistical models to assess seroprevalence within the French population.</p> Results <p>The analysis of 2132 serum samples from French children and adults reveals notable variation in seroprevalence among different age groups. Consistently high seroprevalence for endemic viruses is observed across all age groups, suggesting widespread exposure from a young age and continuous exposure throughout life. Similarly, mandatory vaccine seroprevalence remains consistently high, reflecting a strong vaccination coverage in France.</p> Conclusions <p>These findings highlight the potential of high-throughput multiplex serology assays for routine surveillance of common viral infections and assessment of vaccine coverage.</p>

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Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月13日

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  • Emma Bloch,
  • Gaëlle Baudemont,
  • Françoise Donnadieu,
  • Laura Garcia,
  • Stéphane Pelleau,
  • Laurie Pinaud,
  • Marie-Noëlle Ungeheuer,
  • Sandrine Fernandes Pellerin,
  • Raphaël Guiheneuf,
  • Etienne Brochot,
  • Sandrine Castelain,
  • Christéle Gras-Le Guen,
  • Olivier Augereau,
  • Laurent Abel,
  • Andres Alcover,
  • Hugues Aschard,
  • Philippe Bousso,
  • Nollaig Bourke,
  • Petter Brodin,
  • Pierre Bruhns,
  • Nadine Cerf-Bensussan,
  • Ana Cumano,
  • Christophe D’Enfert,
  • Caroline Demangel,
  • Ludovic Deriano,
  • Marie-Agnès Dillies,
  • James Di Santo,
  • Gérard Eberl,
  • Jost Enninga,
  • Jacques Fellay,
  • Ivo Gomperts-Boneca,
  • Milena Hasan,
  • Gunilla Karlsson Hedestam,
  • Serge Hercberg,
  • Molly A. Ingersoll,
  • Olivier Lantz,
  • Rose Anne Kenny,
  • Mickaël Ménager,
  • Hugo Mouquet,
  • Cliona O’Farrelly,
  • Etienne Patin,
  • Antonio Rausell,
  • Frédéric Rieux-Laucat,
  • Lars Rogge,
  • Magnus Fontes,
  • Anavaj Sakuntabhai,
  • Olivier Schwartz,
  • Benno Schwikowski,
  • Spencer Shorte,
  • Frédéric Tangy,
  • Antoine Toubert,
  • Mathilde Touvier,
  • Christophe Zimmer,
  • Matthew L. Albert,
  • Lluis Quintana-Murci,
  • Darragh Duffy,
  • Arnaud Fontanet,
  • Michael White

摘要

Background

Vaccine-preventable diseases and common viral infections pose substantial public health challenges worldwide. Applying multiplex serological assays to samples collected from cross-sectional studies allows assessment of population-level immunity to a broad range of pathogens.

Methods

We develop a high-throughput multiplex serological assay using bead-based Luminex technology to measure IgG antibody responses to a broad panel of pathogens. Vaccine preventable diseases include pertussis, diphtheria, tetanus, measles, mumps, and rubella. Common viral infections include adenovirus, cytomegalovirus, Epstein-Barr virus, chickenpox, respiratory syncytial virus, echovirus, Coxsackie B virus, rhinovirus, norovirus, rotavirus, influenza A, hepatitis A, hepatitis E, and the seasonal coronaviruses 229E, OC43, NL63, and HKU1. Measured antibody responses are analysed with statistical models to assess seroprevalence within the French population.

Results

The analysis of 2132 serum samples from French children and adults reveals notable variation in seroprevalence among different age groups. Consistently high seroprevalence for endemic viruses is observed across all age groups, suggesting widespread exposure from a young age and continuous exposure throughout life. Similarly, mandatory vaccine seroprevalence remains consistently high, reflecting a strong vaccination coverage in France.

Conclusions

These findings highlight the potential of high-throughput multiplex serology assays for routine surveillance of common viral infections and assessment of vaccine coverage.