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<p>Fluidic force microscopy is a versatile bionanotechnology platform that integrates atomic force microscopy with microfluidic probes. This hybrid approach enables precise measurement and application of forces across sub-nanonewton to micronewton ranges while simultaneously dispensing or sampling sub-femtolitre to picolitre volumes, all with real-time optical visualization at sub-micrometre resolution. In recent years, fluidic force microscopy has emerged as an enabling tool for minimally invasive single-cell manipulation, subcellular analysis and high-resolution nanoprinting applications. This Primer describes the fundamental principles underlying the combination of atomic force microscopy with microchannelled cantilevers, providing a comprehensive framework for understanding the unique capabilities of fluidic force microscopy and its rapidly expanding range of applications in biological research and nanotechnology.</p>

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Fluidic force microscopy

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Tomaso Zambelli,
  • Orane Guillaume-Gentil,
  • Edin Sarajlic,
  • Georg Papastavrou,
  • Robert Horvath,
  • Gang-yu Liu,
  • Mi Li,
  • Julia A. Vorholt

摘要

Fluidic force microscopy is a versatile bionanotechnology platform that integrates atomic force microscopy with microfluidic probes. This hybrid approach enables precise measurement and application of forces across sub-nanonewton to micronewton ranges while simultaneously dispensing or sampling sub-femtolitre to picolitre volumes, all with real-time optical visualization at sub-micrometre resolution. In recent years, fluidic force microscopy has emerged as an enabling tool for minimally invasive single-cell manipulation, subcellular analysis and high-resolution nanoprinting applications. This Primer describes the fundamental principles underlying the combination of atomic force microscopy with microchannelled cantilevers, providing a comprehensive framework for understanding the unique capabilities of fluidic force microscopy and its rapidly expanding range of applications in biological research and nanotechnology.