Scholarlink

<p>Drug-resistant bacteria, bacterial biofilms and toxins impede skin wound healing. Traditional medical dressings, such as gauzes, serve merely as physical barriers and are insufficient to prevent bacterial adhesion and invasion. Herein, we present a composite nonwoven fabric dressing (PVA@HD5-myr) by covalently conjugating multi-bioactive human α defensin 5 derivative (HD5-myr) to polyvinyl alcohol (PVA). PVA@HD5-myr fibers are produced in one step by incorporating Tyzor®LA, a titanate coupling agent, into the spinning dope during the spinning process. The resulting PVA@HD5-myr demonstrates satisfactory antibacterial activity against multiple drug-resistant bacteria through adhesion and cell membrane disruption. Additionally, PVA@HD5-myr effectively inhibits biofilm formation on its surface, blocks bacterial invasion, and significantly promotes wound healing in vivo. This dressing also disrupts endotoxin release in skin wound environments, with favorable safety profiles both in vitro and in vivo assessments. Our findings suggest that PVA@HD5-myr is a promising candidate for next-generation clinical dressings, offering effective antimicrobial properties alongside wound protection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Defensin-conjugated polymer fabrics combat drug-resistant biofilms and toxins in skin wounds

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月15日

查看全文
  • Yaqi Sun,
  • Hui Ye,
  • Liman Hao,
  • Yang Li,
  • Jinchao Hou,
  • Yan Zhang,
  • Qixing Chen,
  • Guohao Xie,
  • Hui Li,
  • Zhinan Xu,
  • Yan Wang,
  • Qiang Shu,
  • Ruyi Lei,
  • Xiangming Fang

摘要

Drug-resistant bacteria, bacterial biofilms and toxins impede skin wound healing. Traditional medical dressings, such as gauzes, serve merely as physical barriers and are insufficient to prevent bacterial adhesion and invasion. Herein, we present a composite nonwoven fabric dressing (PVA@HD5-myr) by covalently conjugating multi-bioactive human α defensin 5 derivative (HD5-myr) to polyvinyl alcohol (PVA). PVA@HD5-myr fibers are produced in one step by incorporating Tyzor®LA, a titanate coupling agent, into the spinning dope during the spinning process. The resulting PVA@HD5-myr demonstrates satisfactory antibacterial activity against multiple drug-resistant bacteria through adhesion and cell membrane disruption. Additionally, PVA@HD5-myr effectively inhibits biofilm formation on its surface, blocks bacterial invasion, and significantly promotes wound healing in vivo. This dressing also disrupts endotoxin release in skin wound environments, with favorable safety profiles both in vitro and in vivo assessments. Our findings suggest that PVA@HD5-myr is a promising candidate for next-generation clinical dressings, offering effective antimicrobial properties alongside wound protection.