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<p>Obesity and inactivity are linked to endothelial dysfunction and atherosclerosis. In this secondary analysis of the S-LiTE trial (ClinicalTrials.gov identifier: <a href="https://clinicaltrials.gov/study/NCT04122716">NCT04122716</a>; EudraCT identifier: <a href="https://www.clinicaltrialsregister.eu/ctr-search/search?query=2015-005585-32">2015–005585-32</a>), 130 adults with obesity completed a diet-induced weight loss plan, followed by randomization to weight maintenance with exercise and/or liraglutide for 52 weeks. We show that exercise, alone or in combination with liraglutide, reduces carotid intima-media thickness and systemic pro-inflammatory cytokine levels (interleukin-6 and interferon-γ). Combination treatment also improves endothelial function biomarkers (sICAM-1, sVCAM-1 and tPA). Liraglutide alone shows no such improvements. Overall, regular physical activity, with or without GLP-1R agonists, is essential for promoting vascular health in adults with obesity.</p>

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Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月24日

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  • Rasmus Michael Sandsdal,
  • Joachim Holt,
  • Haithem Ghalib Ali Alkhefagie,
  • Julie Rehné Jørgensen,
  • Christian Rimer Juhl,
  • Lisa M. Olsen,
  • Sarah Byberg,
  • Roopameera Thirumathyam,
  • Lasse Gliemann,
  • Bente Stallknecht,
  • Jens Juul Holst,
  • Jens Dahlgaard Hove,
  • Thomas Bandholm,
  • Kirstine Nyvold Bojsen-Møller,
  • Sten Madsbad,
  • Joachim Størling,
  • Else Marie Bladbjerg,
  • Charalambos Antoniades,
  • Simon Birk Kjær Jensen,
  • Signe Sørensen Torekov

摘要

Obesity and inactivity are linked to endothelial dysfunction and atherosclerosis. In this secondary analysis of the S-LiTE trial (ClinicalTrials.gov identifier: NCT04122716; EudraCT identifier: 2015–005585-32), 130 adults with obesity completed a diet-induced weight loss plan, followed by randomization to weight maintenance with exercise and/or liraglutide for 52 weeks. We show that exercise, alone or in combination with liraglutide, reduces carotid intima-media thickness and systemic pro-inflammatory cytokine levels (interleukin-6 and interferon-γ). Combination treatment also improves endothelial function biomarkers (sICAM-1, sVCAM-1 and tPA). Liraglutide alone shows no such improvements. Overall, regular physical activity, with or without GLP-1R agonists, is essential for promoting vascular health in adults with obesity.