Scholarlink

<p>Despite the high prevalence of neurodevelopmental disorders, the influence of maternal diet during pregnancy on child neurodevelopment remains understudied. Here we show that a western dietary pattern during pregnancy is associated with child neurodevelopmental disorders. We analyse self-reported maternal dietary patterns at 24 weeks of pregnancy and clinically evaluated neurodevelopmental disorders at 10 years of age in the COPSAC2010 cohort (<i>n</i> = 508). We find significant associations with attention-deficit hyperactivity disorder (ADHD) and autism diagnoses. We validate the ADHD findings in three large, independent mother–child cohorts (<i>n</i> = 59,725, <i>n</i> = 656 and <i>n</i> = 348) through self-reported dietary modelling, maternal blood metabolomics and foetal blood metabolomics. Metabolome analyses identify 15 mediating metabolites in pregnancy that improve ADHD prediction. Longitudinal blood metabolome analyses, incorporating five time points per cohort in two independent cohorts, reveal that associations between western dietary pattern metabolite scores and neurodevelopmental outcomes are consistently significant in early–mid-pregnancy. These findings highlight the potential for targeted prenatal dietary interventions to prevent neurodevelopmental disorders and emphasise the importance of early intervention.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence

  • 期刊论文

  • 发表日期：

    2025年3月3日

查看全文
  • David Horner,
  • Jens Richardt M. Jepsen,
  • Bo Chawes,
  • Kristina Aagaard,
  • Julie B. Rosenberg,
  • Parisa Mohammadzadeh,
  • Astrid Sevelsted,
  • Nilo Vahman,
  • Rebecca Vinding,
  • Birgitte Fagerlund,
  • Christos Pantelis,
  • Niels Bilenberg,
  • Casper-Emil T. Pedersen,
  • Anders Eliasen,
  • Sarah Brandt,
  • Yulu Chen,
  • Nicole Prince,
  • Su H. Chu,
  • Rachel S. Kelly,
  • Jessica Lasky-Su,
  • Thorhallur I. Halldorsson,
  • Marin Strøm,
  • Katrine Strandberg-Larsen,
  • Sjurdur F. Olsen,
  • Birte Y. Glenthøj,
  • Klaus Bønnelykke,
  • Bjørn H. Ebdrup,
  • Jakob Stokholm,
  • Morten Arendt Rasmussen

摘要

Despite the high prevalence of neurodevelopmental disorders, the influence of maternal diet during pregnancy on child neurodevelopment remains understudied. Here we show that a western dietary pattern during pregnancy is associated with child neurodevelopmental disorders. We analyse self-reported maternal dietary patterns at 24 weeks of pregnancy and clinically evaluated neurodevelopmental disorders at 10 years of age in the COPSAC2010 cohort (n = 508). We find significant associations with attention-deficit hyperactivity disorder (ADHD) and autism diagnoses. We validate the ADHD findings in three large, independent mother–child cohorts (n = 59,725, n = 656 and n = 348) through self-reported dietary modelling, maternal blood metabolomics and foetal blood metabolomics. Metabolome analyses identify 15 mediating metabolites in pregnancy that improve ADHD prediction. Longitudinal blood metabolome analyses, incorporating five time points per cohort in two independent cohorts, reveal that associations between western dietary pattern metabolite scores and neurodevelopmental outcomes are consistently significant in early–mid-pregnancy. These findings highlight the potential for targeted prenatal dietary interventions to prevent neurodevelopmental disorders and emphasise the importance of early intervention.