<p>Mobility-targeted interventions have proven effective in curbing the transmission of airborne diseases. However, their impact on vector-borne diseases remains less well understood. In this study, we introduce a framework that integrates mobility data with vulnerability matrices to evaluate the differential effects of mobility-targeted interventions on both airborne and vector-borne pathogens. Focusing on the city of Santiago de Cali in Colombia, our analysis illustrates how mobility policies previously proposed to contain airborne disease may inadvertently increase vulnerability to vector-borne disease transmission. To explain this trade-off, we develop a simplified synthetic model that highlights the limitations of these policies and identifies interventions that leverage the distinct dynamics of each disease class. By reshaping the mobility network, our proposed strategies enable the simultaneous mitigation of both disease types. These results offer key insights into the design of mobility-targeted interventions and the management of co-circulating pathogens in urban environments.</p>