<p>Nanoconfined fluid is central to many engineering applications such as shale energy production, carbon sequestration, and molecular separations. While classical molecular dynamics (MD) simulation provides essential atomistic detail, its prohibitive computational cost severely limits accessible time and length scales. Hybrid MD-Monte Carlo (MDMC) methods accelerate sampling but lack generality beyond their trained conditions. In this work, we introduce an AI-assisted MDMC framework that overcomes this limitation by learning local, conditional transition statistics directly from MD trajectories. Our method encodes molecular motion into a compact set of neural network-predicted displacement actions, preserving MD-level accuracy within a drastically reduced dimensionality. This approach enables efficient sampling with robust generality. We systematically demonstrate the framework’s accuracy and transferability across diverse thermodynamic conditions (temperature, pressure), spatial scales, and complex nano-scale geometries, establishing a versatile path for simulating confined fluid phenomena relevant to engineering applications.</p>