Scholarlink

<p>Photocages are widely investigated for their bioimaging, controlled drug release, and cellular process modulation. Developing universal photoactive units can significantly expand the structural diversity of photocages. Herein, we developed a class of photoactive units based on the classic aldehyde-hydrazone moiety by conjugating several fluorescent aldehydes with various substituted phenylhydrazines. The resulting hydrazone-based photocages degraded upon exposure to light (365-450 nm), releasing fluorescent aldehydes. Fluorescent enhancements, redshifts or blueshifts were clearly observed during uncaging. For bio-application, morpholine-hydrazone based hybrid <b>BW3MP</b>, <i>staurosporine</i>-derived hybrids <b>BW3STS</b> and <b>FY4STS</b> were constructed. They exhibited high release efficiencies of MP (75.5%, <b>BW3MP</b>) and <b>STSA</b> (65.3%, <b>BW3STS</b>), respectively. <b>BW3MP</b> co-localized with a lysosome dye, exhibiting a Pearson correlation coefficient of 0.94. The biological activity of <b>BW3STS</b> was unmasked under irradiation, with a 4-fold increase in IC<sub>50</sub>. Our work developed photoactive units that hold significant promise for the constitution of general suitable drug delivery systems (DDSs).</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Hydrazone-based photocages for precise sub-organelle visualization and drug release

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月7日

查看全文
  • Xia Wang,
  • Jingming Zhou,
  • Yu Cheng,
  • Hongmei Wu,
  • Xuejing Su,
  • Rundong Wang,
  • Kaiyan Xiao,
  • Weiwei Zhang,
  • Zhong Chen,
  • Bing Xu,
  • Yusheng Lu,
  • Hongqiang Qiu,
  • Lijun Xie

摘要

Photocages are widely investigated for their bioimaging, controlled drug release, and cellular process modulation. Developing universal photoactive units can significantly expand the structural diversity of photocages. Herein, we developed a class of photoactive units based on the classic aldehyde-hydrazone moiety by conjugating several fluorescent aldehydes with various substituted phenylhydrazines. The resulting hydrazone-based photocages degraded upon exposure to light (365-450 nm), releasing fluorescent aldehydes. Fluorescent enhancements, redshifts or blueshifts were clearly observed during uncaging. For bio-application, morpholine-hydrazone based hybrid BW3MP, staurosporine-derived hybrids BW3STS and FY4STS were constructed. They exhibited high release efficiencies of MP (75.5%, BW3MP) and STSA (65.3%, BW3STS), respectively. BW3MP co-localized with a lysosome dye, exhibiting a Pearson correlation coefficient of 0.94. The biological activity of BW3STS was unmasked under irradiation, with a 4-fold increase in IC50. Our work developed photoactive units that hold significant promise for the constitution of general suitable drug delivery systems (DDSs).