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<p>The functionalization of challenging unactivated C(<i>sp</i><sup>3</sup>)–H bonds was achieved electrocatalytically <i>via</i> hydrogen atom transfer and without mediators. This was possible through the sole activation of the surface of the Glassy Carbon Electrode (GCE) in an electrochemical fashion using a phosphate buffer. This activation produced oxygenated functional groups on the surface, capable of abstracting these hydrogen atoms from C(<i>sp</i><sup>3</sup>)–H of alkanes. Minisci and Ritter-type reactions were achieved using this procedure. Extensive characterization of the activated GCE (AGCE) and preliminary mechanistic studies allow us to propose plausible reaction mechanisms. Furthermore, a regular battery can be used within this protocol to achieve the desired substituted alkanes under inexpensive and user-friendly conditions.</p><p></p>

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Electrochemical heteroarylation and amidation of alkanes using activated glassy carbon electrodes without mediators

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月29日

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  • Loris Laze,
  • Jose C. Gonzalez-Gomez,
  • Irene Bosque

摘要

The functionalization of challenging unactivated C(sp3)–H bonds was achieved electrocatalytically via hydrogen atom transfer and without mediators. This was possible through the sole activation of the surface of the Glassy Carbon Electrode (GCE) in an electrochemical fashion using a phosphate buffer. This activation produced oxygenated functional groups on the surface, capable of abstracting these hydrogen atoms from C(sp3)–H of alkanes. Minisci and Ritter-type reactions were achieved using this procedure. Extensive characterization of the activated GCE (AGCE) and preliminary mechanistic studies allow us to propose plausible reaction mechanisms. Furthermore, a regular battery can be used within this protocol to achieve the desired substituted alkanes under inexpensive and user-friendly conditions.