Scholarlink

<p>Microbial biosynthetic gene clusters (BGCs) encode diverse bioactive molecules but remain mostly silent under lab conditions, reflecting a balance between regulatory control and the metabolic cost of secondary metabolite production. While activation strategies exist, the yields stay low because switching on a cluster doesn’t guarantee the host can sustain biosynthesis. This review covers the regulatory architecture and metabolic constraints, including precursor availability, energy status, and nutrient sensing, that shape BGC output. We argue that coupling regulatory network models with genome-scale metabolic models offers a powerful framework for unlocking silent BGCs and realising the full biosynthetic potential within microbial genomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Regulatory and metabolic control of microbial biosynthetic gene clusters

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月17日

查看全文
  • Idris Matine,
  • Frederick Clasen,
  • Fernando Garcia Guevara,
  • Miao Guo,
  • Saeed Shoaie

摘要

Microbial biosynthetic gene clusters (BGCs) encode diverse bioactive molecules but remain mostly silent under lab conditions, reflecting a balance between regulatory control and the metabolic cost of secondary metabolite production. While activation strategies exist, the yields stay low because switching on a cluster doesn’t guarantee the host can sustain biosynthesis. This review covers the regulatory architecture and metabolic constraints, including precursor availability, energy status, and nutrient sensing, that shape BGC output. We argue that coupling regulatory network models with genome-scale metabolic models offers a powerful framework for unlocking silent BGCs and realising the full biosynthetic potential within microbial genomes.