Scholarlink

<p>The Dbf4‑dependent kinase (DDK), composed of the catalytic subunit Cdc7 and the regulatory subunit Dbf4, is a serine/threonine kinase traditionally defined as an essential activator of DNA replication. Here, we review DDK function from three complementary perspectives: its temporal regulation during the cell cycle, its spatial organization on chromosomes, and its expanding substrate repertoire. These perspectives reveal that DDK acts beyond DNA replication, targeting proteins involved in chromosome segregation, DNA damage responses and homologous recombination. Together, they redefine DDK as multifunctional genome integrity kinase which coordinates cell cycle progression and genome stability offering a unique therapeutic potential in cancer therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月23日

查看全文
  • Lorenzo Galanti,
  • Boris Pfander

摘要

The Dbf4‑dependent kinase (DDK), composed of the catalytic subunit Cdc7 and the regulatory subunit Dbf4, is a serine/threonine kinase traditionally defined as an essential activator of DNA replication. Here, we review DDK function from three complementary perspectives: its temporal regulation during the cell cycle, its spatial organization on chromosomes, and its expanding substrate repertoire. These perspectives reveal that DDK acts beyond DNA replication, targeting proteins involved in chromosome segregation, DNA damage responses and homologous recombination. Together, they redefine DDK as multifunctional genome integrity kinase which coordinates cell cycle progression and genome stability offering a unique therapeutic potential in cancer therapy.