Scholarlink

<p>Long non-coding RNAs (lncRNAs) are critical context-dependent regulators of viral infection, functioning as double-edged swords in host defense and viral pathogenesis. Accumulating evidence demonstrates that host lncRNAs exert antiviral effects by modulating innate immune responses, regulating host cell survival/apoptosis, or directly targeting viral genomes. Conversely, viruses exploit lncRNA functions to evade immune surveillance, suppress antiviral signaling, and promote viral replication. This review synthesizes current literature to elucidate the molecular mechanisms governing the functional duality of lncRNAs and their dynamic switching between proviral and antiviral roles during infection. Understanding the precise control of this functional switch is crucial for translating lncRNA biology into novel therapeutic strategies. The functional duality of lncRNAs reflects their deep integration into cellular networks. Harnessing their potential demands mechanistic understanding, precision diagnostics, and dynamically responsive interventions. Key lncRNA-pathway interactions offer promising targets for rationally designed RNA-based antivirals against chronic and drug-resistant viruses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Janus face of host LncRNA in viral infections: Defender or collaborator?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月7日

查看全文
  • Longying Ding,
  • Guohua Pei,
  • Ziqiang Cheng

摘要

Long non-coding RNAs (lncRNAs) are critical context-dependent regulators of viral infection, functioning as double-edged swords in host defense and viral pathogenesis. Accumulating evidence demonstrates that host lncRNAs exert antiviral effects by modulating innate immune responses, regulating host cell survival/apoptosis, or directly targeting viral genomes. Conversely, viruses exploit lncRNA functions to evade immune surveillance, suppress antiviral signaling, and promote viral replication. This review synthesizes current literature to elucidate the molecular mechanisms governing the functional duality of lncRNAs and their dynamic switching between proviral and antiviral roles during infection. Understanding the precise control of this functional switch is crucial for translating lncRNA biology into novel therapeutic strategies. The functional duality of lncRNAs reflects their deep integration into cellular networks. Harnessing their potential demands mechanistic understanding, precision diagnostics, and dynamically responsive interventions. Key lncRNA-pathway interactions offer promising targets for rationally designed RNA-based antivirals against chronic and drug-resistant viruses.