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<p>The black rockfish (<i>Sebastes schlegelii</i>) is a viviparous teleost with high fecundity and prolonged female sperm storage for about six months despite lacking a specialized storage organ. During gestation, its ovarian stroma undergoes a functional shift from supporting oocyte growth to maintaining embryo development, resembling the maternal decidua in mammals. Here, we present a single-cell atlas of the ovarian stroma across unfertilized, normal-gestation, and abnormal-gestation states. Cross-species integration with human and mouse datasets reveals convergence on decidualization-like programs during early pregnancy, while highlighting lineage-specific implementation by distinct cell types. We further implicate annexins in ovarian sperm storage and show that abnormal-gestation is associated with lymphatic endothelial skewing and lipid-handling signatures, consistent with stromal lipid recapture. Together, these findings provide a framework for the maternal contribution to teleost placentation and reveal convergent, placenta-like adaptations underlying viviparity.</p>

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Comparative single-cell analysis of black rockfish (Sebastes schlegelii) ovarian stroma reveals placenta-like adaptations toward viviparity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月4日

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  • Xinlin Yang,
  • Jianshuang Li,
  • Bingyan Zheng,
  • Chong Zhang,
  • Haishen Wen,
  • Yun Li,
  • Xin Qi

摘要

The black rockfish (Sebastes schlegelii) is a viviparous teleost with high fecundity and prolonged female sperm storage for about six months despite lacking a specialized storage organ. During gestation, its ovarian stroma undergoes a functional shift from supporting oocyte growth to maintaining embryo development, resembling the maternal decidua in mammals. Here, we present a single-cell atlas of the ovarian stroma across unfertilized, normal-gestation, and abnormal-gestation states. Cross-species integration with human and mouse datasets reveals convergence on decidualization-like programs during early pregnancy, while highlighting lineage-specific implementation by distinct cell types. We further implicate annexins in ovarian sperm storage and show that abnormal-gestation is associated with lymphatic endothelial skewing and lipid-handling signatures, consistent with stromal lipid recapture. Together, these findings provide a framework for the maternal contribution to teleost placentation and reveal convergent, placenta-like adaptations underlying viviparity.