Scholarlink

<p>The global spread of multidrug-resistant <i>Staphylococcus aureus</i> (MRSA) poses serious threats to public health and food safety. In this study, the antibacterial potential of the anthraquinone compound 13394-2, derived from soil actinomycetes, was systematically evaluated. In vitro, 13394-2 exhibited potent activity (MIC as low as 0.25 μg/mL), rapid bactericidal effects, biofilm clearance, and concentration-dependent killing. Mechanistic studies revealed that membrane disruption, ROS accumulation, and ATP depletion are key bactericidal pathways leading to metabolic collapse. Transcriptomic, computational analyses and biophysical experiments revealed significant interference with protein, energy, and fatty acid metabolism, with FabF identified as a potential target. Toxicity assessments confirmed low cytotoxicity and good in vivo safety. In animal infection models, 13394-2 improved survival, reduced bacterial burden and tissue damage, and promoted wound healing. It also effectively eliminated drug-resistant <i>S. aureus</i> in simulated food and surface contamination models. These findings support the potential of anthraquinones as potential antibiotics against drug-resistant infections and environmental contamination.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Anthraquinones derived from soil actinomycetes combat multidrug-resistant Staphylococcus aureus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月28日

查看全文
  • Chenchen Wang,
  • Xiaodan Li,
  • Ziyi Zhang,
  • Di Liu,
  • Zhaoran Zhang,
  • Wei Fang,
  • Shaoyong Ke,
  • Chen Tan,
  • Zhaoyuan Wu,
  • Manli Liu

摘要

The global spread of multidrug-resistant Staphylococcus aureus (MRSA) poses serious threats to public health and food safety. In this study, the antibacterial potential of the anthraquinone compound 13394-2, derived from soil actinomycetes, was systematically evaluated. In vitro, 13394-2 exhibited potent activity (MIC as low as 0.25 μg/mL), rapid bactericidal effects, biofilm clearance, and concentration-dependent killing. Mechanistic studies revealed that membrane disruption, ROS accumulation, and ATP depletion are key bactericidal pathways leading to metabolic collapse. Transcriptomic, computational analyses and biophysical experiments revealed significant interference with protein, energy, and fatty acid metabolism, with FabF identified as a potential target. Toxicity assessments confirmed low cytotoxicity and good in vivo safety. In animal infection models, 13394-2 improved survival, reduced bacterial burden and tissue damage, and promoted wound healing. It also effectively eliminated drug-resistant S. aureus in simulated food and surface contamination models. These findings support the potential of anthraquinones as potential antibiotics against drug-resistant infections and environmental contamination.