Scholarlink

<p>The naked mole-rat <i>Heterocephalus</i>, a hairless, subterranean rodent from the Horn of Africa, has attracted scientific interest due to its cooperative breeding, poikilothermy, longevity, resistance to cancer, and tolerance to pain and hypoxia, among others. Genomic analyses of <i>H. glaber</i>, traditionally considered a single species, reveal three highly divergent lineages. One of these, identified as <i>H. phillipsi</i> Thomas 1885, shows deep genetic divergence (~4.1 Ma) and distinct morphology, notably reduced third molars, warranting recognition as a distinct species. The remaining two lineages, previously designated as the subspecies <i>H. g. glaber</i> Rüppell 1842 and <i>H. g. ansorgei</i> Thomas 1903, diverged around 2.3 Ma and their morphological differentiation is less pronounced. Each of the lineages occupies distinct environmental conditions, with <i>H. phillipsi</i> inhabiting extremely harsh habitats. The finding of an unexpected diversity within this key biomedical model opens new avenues across various fields of research.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

More than one species of the naked mole-rat, a new biomedical model

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月9日

查看全文
  • Michaela Uhrová,
  • Ondřej Mikula,
  • Josef Bryja,
  • Petra Frýdlová,
  • Elena D. Zemlemerova,
  • Hassan S. A. Elmi,
  • Iveta Štolhoferová,
  • Veronika Tymlová,
  • Václav Maštera,
  • Daniel Frynta,
  • Leonid A. Lavrenchenko,
  • Radim Šumbera

摘要

The naked mole-rat Heterocephalus, a hairless, subterranean rodent from the Horn of Africa, has attracted scientific interest due to its cooperative breeding, poikilothermy, longevity, resistance to cancer, and tolerance to pain and hypoxia, among others. Genomic analyses of H. glaber, traditionally considered a single species, reveal three highly divergent lineages. One of these, identified as H. phillipsi Thomas 1885, shows deep genetic divergence (~4.1 Ma) and distinct morphology, notably reduced third molars, warranting recognition as a distinct species. The remaining two lineages, previously designated as the subspecies H. g. glaber Rüppell 1842 and H. g. ansorgei Thomas 1903, diverged around 2.3 Ma and their morphological differentiation is less pronounced. Each of the lineages occupies distinct environmental conditions, with H. phillipsi inhabiting extremely harsh habitats. The finding of an unexpected diversity within this key biomedical model opens new avenues across various fields of research.