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<p>Research on the role of probiotics in maintaining locomotor function in aged <i>Caenorhabditis elegans</i> is limited. Therefore, we investigated whether a probiotic strain, <i>Bacillus subtilis</i> TO-A (BSTOA), which extends the lifespan of worms can prevent age-related declines in the locomotor functions of aged worms. This study revealed that aged worms fed BSTOA (BSTOA_day13) maintained better locomotor function than those fed <i>Escherichia coli</i> OP50 (OP50_day13). BSTOA_day13 exhibited better activity than OP50_day13 in maintaining actin structure during age-related changes in body wall muscles. Notably, the expression levels of oxidative stress-related genes fluctuated in BSTOA_day13; these worms also displayed high survival rates based on the paraquat assay. An examination of the locomotor function of aged <i>gpx-7</i> mutants revealed that even worms fed BSTOA had a reduced thrashing rate. Therefore, consuming BSTOA may prevent the decline in age-related locomotor functions, such as symptoms of sarcopenia in humans, by inhibiting the decrease in <i>gpx-7</i> expression in aged worms.</p>

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Bacillus subtilis TO-A suppresses the age-related decline in locomotion in Caenorhabditis elegans

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月22日

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  • Rika Inomata,
  • Ryuichi Saito,
  • Diansheng Wang,
  • Satoshi Shimazaki

摘要

Research on the role of probiotics in maintaining locomotor function in aged Caenorhabditis elegans is limited. Therefore, we investigated whether a probiotic strain, Bacillus subtilis TO-A (BSTOA), which extends the lifespan of worms can prevent age-related declines in the locomotor functions of aged worms. This study revealed that aged worms fed BSTOA (BSTOA_day13) maintained better locomotor function than those fed Escherichia coli OP50 (OP50_day13). BSTOA_day13 exhibited better activity than OP50_day13 in maintaining actin structure during age-related changes in body wall muscles. Notably, the expression levels of oxidative stress-related genes fluctuated in BSTOA_day13; these worms also displayed high survival rates based on the paraquat assay. An examination of the locomotor function of aged gpx-7 mutants revealed that even worms fed BSTOA had a reduced thrashing rate. Therefore, consuming BSTOA may prevent the decline in age-related locomotor functions, such as symptoms of sarcopenia in humans, by inhibiting the decrease in gpx-7 expression in aged worms.