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<p>Neuroinflammation is a key factor in Parkinson’s disease (PD) pathogenesis. However, the regional heterogeneity of biomarkers related to inflammation in PD is less well defined. We developed [<sup>18</sup>F]GSK PET imaging to quantify neuroinflammation via the P2X7 receptor&#xa0;(P2X7R) in A53T PD male mice and wild-type (WT) male mice. Montelukast (MK) was administered to mice, and weekly behavior tests confirmed MK’s efficacy. [<sup>18</sup>F]L-DOPA/[<sup>18</sup>F]GSK PET, motor testing, autoradiography, and immunofluorescence were performed after MK treatments. MK improved motor function and reduced the brain uptake of [<sup>18</sup>F]GSK, indicating resynchronization of regional microglial activity. The whole brain uptake of [<sup>18</sup>F]GSK was correlated with motor functional restoration, while [<sup>18</sup>F]L-DOPA PET was not. Overall, our study indicated that brain mapping of [<sup>18</sup>F]GSK PET is beneficial for exploring P2X7R-related neuroinflammation, which is correspondent to motor function in PD.</p><p></p>

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Resynchronization of microglial activity in the brain is associated with restoration of motor function in Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月9日

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  • Peizhen Ye,
  • Lei Bi,
  • Yifan Qiu,
  • Min Yang,
  • Yongshan Liu,
  • Yuyi Hou,
  • Pengcheng Zheng,
  • Xiaojuan Cao,
  • Jing Su,
  • Hongjun Jin

摘要

Neuroinflammation is a key factor in Parkinson’s disease (PD) pathogenesis. However, the regional heterogeneity of biomarkers related to inflammation in PD is less well defined. We developed [18F]GSK PET imaging to quantify neuroinflammation via the P2X7 receptor (P2X7R) in A53T PD male mice and wild-type (WT) male mice. Montelukast (MK) was administered to mice, and weekly behavior tests confirmed MK’s efficacy. [18F]L-DOPA/[18F]GSK PET, motor testing, autoradiography, and immunofluorescence were performed after MK treatments. MK improved motor function and reduced the brain uptake of [18F]GSK, indicating resynchronization of regional microglial activity. The whole brain uptake of [18F]GSK was correlated with motor functional restoration, while [18F]L-DOPA PET was not. Overall, our study indicated that brain mapping of [18F]GSK PET is beneficial for exploring P2X7R-related neuroinflammation, which is correspondent to motor function in PD.