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<p>Behavioral challenges prompt alternating vigorous and reduced mobility – active, passive coping – that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion–related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.</p>

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Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月22日

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  • Léo Michel,
  • Denys Osypenko,
  • Patricia Molina,
  • Kadir A. Mutlu,
  • Salvatore Lecca,
  • Chihiro Hisatsune,
  • Katsuhiko Mikoshiba,
  • Toko Kikuchi,
  • Emre Yaksi,
  • Andrea Volterra,
  • Manuel Mameli

摘要

Behavioral challenges prompt alternating vigorous and reduced mobility – active, passive coping – that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion–related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.