Scholarlink

<p>Comparative studies of social interaction in the presence of physical contact (SIPPC) and social interaction in absence of physical contact (SIAPC) enhance our understanding of the neurophysiological mechanisms underlying these activities. We analyzed comparatively the effects of SIPPC and SIAPC on c-fos expression across 100 brain regions in mice, and found that SIPPC activated a broader range of brain regions, particularly those associated with emotion and reward. Subsequent observations of brain activity coordination and network construction highlighted the critical roles of the infralimbic cortex (IL), lateral septal nucleus intermediate part (LSI), and agranular insular cortex ventral part (AIV) in SIPPC. Additionally, we demonstrated through chemogenetic techniques that inhibiting the activity of AIV, LSI brain regions, or AIV-LSI circuit significantly reduces the tactile contact behavior of mice during SIPPC. To sum up, our findings elucidate the similarities and differences in brain activity and network connectivity between SIPPC and SIAPC, while identifying specific brain regions and neural circuit that may mediate tactile contact in social interaction.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Differential brain activation and network connectivity in social interactions presence and absence of physical contact

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月2日

查看全文
  • Jinhe Zhai,
  • Xinyi Zhang,
  • Xinxin Wang,
  • Zihan Xu,
  • Xueke Yao,
  • Yuying Zhang,
  • Lili Fan,
  • Lijie Wu,
  • Jia Wang

摘要

Comparative studies of social interaction in the presence of physical contact (SIPPC) and social interaction in absence of physical contact (SIAPC) enhance our understanding of the neurophysiological mechanisms underlying these activities. We analyzed comparatively the effects of SIPPC and SIAPC on c-fos expression across 100 brain regions in mice, and found that SIPPC activated a broader range of brain regions, particularly those associated with emotion and reward. Subsequent observations of brain activity coordination and network construction highlighted the critical roles of the infralimbic cortex (IL), lateral septal nucleus intermediate part (LSI), and agranular insular cortex ventral part (AIV) in SIPPC. Additionally, we demonstrated through chemogenetic techniques that inhibiting the activity of AIV, LSI brain regions, or AIV-LSI circuit significantly reduces the tactile contact behavior of mice during SIPPC. To sum up, our findings elucidate the similarities and differences in brain activity and network connectivity between SIPPC and SIAPC, while identifying specific brain regions and neural circuit that may mediate tactile contact in social interaction.