Scholarlink

<p>Convergent adaptations represent paradigmatic examples of the capacity of natural selection to influence organisms’ biology. However, the possibility to investigate the genetic determinants underpinning convergent complex adaptive traits has been offered only recently by methods for inferring polygenic adaptations from genomic data. Relying on this approach, we demonstrate how high-altitude Andean human groups experienced pervasive selective events at angiogenic pathways, which resemble those previously attested for Himalayan populations despite partial convergence at the single-gene level was observed. This provides additional evidence for the drivers of convergent evolution of enhanced blood perfusion in populations exposed to hypobaric hypoxia for thousands of years.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月6日

查看全文
  • Giulia Ferraretti,
  • Aina Rill,
  • Paolo Abondio,
  • Kyra Smith,
  • Claudia Ojeda-Granados,
  • Sara De Fanti,
  • Marta Alberti,
  • Massimo Izzi,
  • Phurba T. Sherpa,
  • Paolo Cocco,
  • Massimiliano Tiriticco,
  • Marco Di Marcello,
  • Agnese Dezi,
  • Guido Alberto Gnecchi-Ruscone,
  • Luca Natali,
  • Angela Corcelli,
  • Giorgio Marinelli,
  • Paolo Garagnani,
  • Davide Peluzzi,
  • Donata Luiselli,
  • Davide Pettener,
  • Stefania Sarno,
  • Marco Sazzini

摘要

Convergent adaptations represent paradigmatic examples of the capacity of natural selection to influence organisms’ biology. However, the possibility to investigate the genetic determinants underpinning convergent complex adaptive traits has been offered only recently by methods for inferring polygenic adaptations from genomic data. Relying on this approach, we demonstrate how high-altitude Andean human groups experienced pervasive selective events at angiogenic pathways, which resemble those previously attested for Himalayan populations despite partial convergence at the single-gene level was observed. This provides additional evidence for the drivers of convergent evolution of enhanced blood perfusion in populations exposed to hypobaric hypoxia for thousands of years.